Stories of men claiming their male genitalia have become larger after regularly taking GLP-1 receptor agonists for weight loss have emerged. Nevertheless, the anecdotes linking these drugs to penile enlargement have circulated across social media and online forums, particularly Reddit, thus sparking curiosity and debate over whether the perceived change is real or merely a visual effect caused by weight loss.
Uncovering the Science Behind Ozempic Penis Phenomenon
A surge of online anecdotes claims male Ozempic users are seeing unexpected changes below the waist. Physicians warn that no evidence links GLP-1 medications to actual genital enlargement.
Background
Note that GLP-1 receptor antagonists are a class of medications used for type 2 diabetes and weight loss. The most popular in the market is semaglutide, or more popularly known as Ozempic and Wegovy. These drugs mimic the action of the natural hormone glucagon-like peptide-1 to help in insulin release, glucagon suppression, and appetite reduction.
The term “Ozempic penis” first emerged around 2023 in online forums like Reddit, and media outlets began reporting about it around June 2025. The discourse centers on testimonies of men who have taken GLP-1 receptor antagonists either to manage their type 2 diabetes or lose weight and noticed a significant change in the size of their male genitalia.
One Reddit user in a thread created in 2024 said he noticed a one-inch increase in the length of his male genital. Another user explained that the increase he experienced was gradual and took several months to become more noticeable while he was using semaglutide for weight loss. Most users who reported the same experience were on a weight-loss regimen.
A June 2025 article by Diabetes.co.uk, which was referenced by the New York Post, has a headline that attributes the trend in average penis size to GLP-1 medications like Ozempic. This is a little bit misleading because the piece explains that the penis tends to get shorter with age because increasing body fat and prostate size draw the penis back into the body.
Medical experts emphasize that there is no scientific evidence linking Ozempic or other GLP-1 medications to actual penile tissue growth. Physician Pamela Tambini, in an interview with the publication Healthline, clarified that no known biological mechanism supports the idea that GLP-1 receptor agonists can stimulate tissue enlargement in the male genitalia.
Explainer
Perceptions of increased size are likely explained by the notable fat-pad reduction around the pubic region. Weight loss, often significant in men taking GLP-1 receptor antagonists like Ozempic, can reduce the fat tissue that partially covers the base of the male genitalia. This uncovering effect makes more of the shaft visible and gives the appearance of enlargement.
Improved vascular health and metabolic function may also influence perceived changes. Weight loss and better cardiometabolic outcomes can enhance erectile quality to make the penis appear fuller, slightly longer, and girthier during erection. Experts also note that improved confidence and body image may further influence how men perceive size.
Measurement inconsistencies contribute to the misperception. Differences in technique, specific state of erection, and environmental factors can make the organ appear longer or thicker when measured under variable conditions. Experts advise that controlled and consistent measurements are essential for accurate comparisons before and after treatment.
Those perceiving changes are advised to consult doctors. Although an improvement in appearance is generally harmless, any alterations in sexual function, sensation, or erectile performance could indicate underlying vascular or metabolic issues. Physicians can evaluate whether these changes are part of normal weight loss effects or a sign of another condition.
In summary, Ozempic penis remains anecdotal. Studies have not documented tissue growth from GLP-1 medications. Men taking GLP-1 medications may perceive increased penis size, but experts attribute this to fat loss, improved erection quality, and psychological perception. Researchers continue to monitor the long-term effects of these drugs on sexual health.
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